Glibenclamide Prevents Diabetes in NOD Mice
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چکیده
منابع مشابه
Glibenclamide Prevents Diabetes in NOD Mice
Previous work has revealed that Cx36, the sole connexin expressed in the insulin-producing beta cells, enhances the secretion of insulin, and promotes the resistance of beta cells against pro-inflammatory cytokines. In parallel, the anti-diabetic sulphonylurea glibenclamide was shown to promote the assembly and function of Cx36 channels. Here, we assessed whether glibenclamide could protect the...
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*Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Kangnam-ku, Seoul 135-710, Korea; †Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, TMP532, P.O. Box 208020, New Haven, CT 06520-8020; and §Department of Pharmacology, School of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jo...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2016
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0168839